Planetary Gasocrinology

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To treat diseases caused by a lack of homeostasis in the endocrine system, one could take a phenotypic or targeted drug screening approach (1). However, when teaching students, it is essential to educate them on the endocrine system, its major components (e.g., hormones and receptors), and feedback loops (2). This raises the question: In the emerging field of gasocrinology, and its specialized branch, planetary gasocrinology, what causes a lack of homeostasis in the gasocrine systems of Earth and other planets?(3, 4) When teaching about pressing problems on Earth due to an imbalance in gas homeostasis , it is important to educate students not only on the gases and their role, but also on gasoreceptors (and perhaps gasoriboceptors) that sense the gases and ensure homeostasis in feedback loops (5–8). This is because, despite advanced qualifications and titles, one will likely be unable to perform in toto phenotypic screening in the field of planetary gasocrinology.

References:

1. Patton EE, Zon LI, Langenau DM. Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials. Nat Rev Drug Discov 20: 611–628, 2021. doi: 10.1038/s41573-021-00210-8.

2. Young JZ. The evolution of the endocrine system. [Summary]. Proc R Soc Med 44: 463–464, 1951.

3. Anbalagan S. Gasocrinology. Zenodo, 2024.

4. Anbalagan S. Gasocrine signaling hypotheses [Online]. Zenodo: 2025. https://zenodo.org/records/13690909 [4 Sept. 2025].

5. Aono S. Gas Sensing in Cells. Royal Society of Chemistry, 2017.

6. Anbalagan S. Heme-based oxygen gasoreceptors. Am J Physiol Endocrinol Metab 326: E178–E181, 2024. doi: 10.1152/ajpendo.00004.2024.

7. Anbalagan S. Vertebrate hemoglobin - a dioxygen transporter or protogasoreceptor? [Online]. Zenodo: 2025. https://zenodo.org/records/16724347 [4 Sept. 2025].

8. Anbalagan S. Gas-sensing riboceptors. RNA Biol 21: 1–6, 2024. doi: 10.1080/15476286.2024.2379607.