Direct and Indirect Genetic Effects of Birthweight Predisposition on Child DNA Methylation at Birth: Supplementary Files

Supplementary file for "Direct and Indirect Genetic Effects of Birthweight Predisposition on Child DNA Methylation at Birth".

Table S1. Regression results for family birthweight polygenic scores predicting child birthweight (grams) adjusted for the polygenic scores or other family members based on three types of model (duo, trio, partitioned effects)

Table S2. Sex-interaction analysis based on a priori GWAS adjusted duo regression models predicting DNA methylation

Table S3. Mother-child duo regression results for child and mother birthweight polygenic scores predicting DNAm at birthweight-associated CpG loci adjusted or unadjusted for the polygenic score of the other family member

Table S4. Trio regression results for child, mother and father birthweight polygenic scores predicting DNAm at birthweight-associated CpG loci adjusted or unadjusted for the polygenic score of the other family members

Table S5. A priori GWAS adjusted duo regression results for fetal-effect and maternal-effect birthweight polygenic scores predicting DNAm at birthweight-associated CpG loci adjusted or unadjusted for the polygenic score of the other family member

Table S6. Annotation

Table S7. Sex-interaction analysis with observed birthweight as outcome

Table S8. Sex-interaction analysis based on a priori GWAS adjusted duo regression models predicting DNA methylation.

Table S9. Mediation of fetal- or maternal-effect PGS on observed birthweight or DNA methylation via prenatal health factors (Standardized estimates)