Published August 30, 2025
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A Global Reference Dataset for Balanced Gene Expression Analysis in Acute Lymphoblastic Leukemia Subtypes
Description
We present a global reference processed, merged, and balanced to ensure
balanced gene expression dataset for fair representation of each subtype. This
Acute Lymphoblastic Leukemia (ALL) resource is suitable for machine learning
subtypes. This dataset integrates 8 publicly applications, biomarker discovery, and
available GEO microarray datasets, resulting translational leukemia research , providing
in 258 samples across 9 ALL subtypes and a reproducible and comprehensive reference
normal controls, with expression values for for the scientific community.
54,675 genes. Data were carefully
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Additional details
Related works
- Is described by
- Dataset: 10.5281/zenodo.17008431 (DOI)
References
- "[1] S. P. Hunger and C. G. Mullighan, 'Acute Lymphoblastic Leukemia in Children,' N. Engl. J. Med., vol. 373, no. 16, pp. 1541–1552, Oct. 2015; [2] C. G. Mullighan et al., 'Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia,' Nature, vol. 446, pp. 758–764, 2007; [3] The Gene Expression Omnibus (GEO) Database, National Center for Biotechnology Information (NCBI), [Online]. Available: https://www.ncbi.nlm.nih.gov/geo/; [4] R. Gentleman et al., Bioconductor: open software development for computational biology and bioinformatics, Genome Biol., vol. 5, no. 10, 2004; [5] S. M. Kornblau et al., 'Integrated genomic and transcriptomic analysis in acute lymphoblastic leukemia,' Leukemia, vol. 27, pp. 2083–2092, 2013; [6] T. M. Cover et al., 'Machine learning approaches for leukemia subtype classification using gene expression,' Bioinformatics, vol. 34, no. 12, pp. 2048–2056, 2018; [7] C. G. Mullighan, 'Molecular genetics of B-precursor acute lymphoblastic leukemia,' J. Clin. Invest., vol. 119, no. 10, pp. 3646–3654, 2009"