Development and Characterization of Nanoemulsion-Based Formulation for Oral Delivery of Itopride

The aim of the current investigation was to screen several excipients for use in the development of Itopride nanoemulsion drug formulations. Nanoemulsions were prepared by the low energy emulsification method. In this method, the oil phase was chosen to be Labrafil M1944CS (Itopride) based on the solubility profiles of each drug in oil. The maximum oil solubilization potential in each surfactant was taken into consideration while choosing Tween-80 (Itopride) as the surfactant. Propylene Glycol was chosen as a cosurfactant based on the maximum nanoemulsion region in the pseudo-ternary phase diagrams. A 1:1, 1:2 and 2:1 (Itopride) mass ratio of surfactant to cosurfactant was chosen in order to select various nanoemulsions based on the phase diagrams maximal nanoemulsion region. It was concluded that every chosen nanoemulsion formulation was thermodynamically stable. The outcomes of these investigations demonstrated that every excipient was appropriately optimized for the formation of the Itopride nanoemulsion formulation.