Published August 10, 2025 | Version v2
Journal article Open

Magnesium Glycinate

  • 1. Keyora NZ Ltd.

Contributors

Project leader:

  • 1. Keyora NZ Ltd.

Description

Abstract


Magnesium glycinate is a bioavailable chelated form of magnesium that plays a key role in neurochemical balance and stress regulation.

This article reviews its mechanisms in modulating GABAergic activity, supporting serotonin synthesis, and attenuating HPA axis hyperactivity.

Evidence from clinical and preclinical studies suggests that magnesium glycinate can alleviate symptoms of depression, anxiety, and insomnia, while enhancing cognitive performance under high-stress conditions.
Its superior absorption profile and low gastrointestinal side effects make it a preferred form for long-term supplementation.

This review also outlines synergistic effects when combined with amino acids, adaptogens, and B vitamins, and discusses optimal dosing and safety considerations for various populations.

Series information

Targeted to alleviate depression, anxiety, and insomnia while enhancing cognitive performance in high-stress individuals.

" Magnesium -The Essential Neuro-Regulating Mineral Magnesium is an essential mineral and electrolyte required for over 300 enzymatic reactions in the human body -often referred to as "the key to neural and metabolic balance".

 Far beyond being just "calcium's partner" or a nutrient for preventing cramps, magnesium plays a fundamental role in nervous system stability, mood regulation, muscle relaxation, heart rhythm maintenance, energy production, and hormonal balance.

Key Functional Roles of Magnesium System Core Function Nervous System.

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Subtitle
"Targeted to alleviate depression, anxiety, and insomnia while enhancing cognitive performance in high-stress individuals."