ASAP Data Repository
Published August 30, 2025 | Version 0.1
Dataset Open

Single-nucleus RNA sequencing of human post-mortem brain tissue from Parkinson's disease and control donors

Authors/Creators

  • 1. Crick
  • 2. UCL/EBI
  • 3. UCL/Cambridge
  • 4. Cambridge
  • 5. European Institute of Oncology
  • 6. UCL

Description

This Zenodo deposit contains a publicly available description of the Dataset:

Title: "Single-nucleus RNA sequencing of human post-mortem brain tissue from Parkinson's disease and control donors".

Description: Single-nucleus RNA-seq data from >740,000 nuclei isolated from eight brain regions of 18 Braak stage 3/4 PD donors and 20 age-matched controls. Nuclei were extracted from frozen tissue using a density gradient protocol and processed with 10x Genomics Single Cell 3' v3.1 (Dual Index) chemistry.

This dataset is made available to researchers via the ASAP CRN Cloud: cloud.parkinsonsroadmap.org. Instructions for how to request access can be found in the User Manual.

This research was funded by the Aligning Science Across Parkinson's Collaborative Research Network (ASAP CRN), through the Michael J. Fox Foundation for Parkinson's Research (MJFF).

This Zenodo deposit was created by the ASAP CRN Cloud staff on behalf of the dataset authors. It provides a citable reference for a CRN Cloud Dataset

Files

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Additional details

Funding

Aligning Science Across Parkinson's
Mapping the PD brain: Oligomer-driven functional genomics. ASAP-000509

References