Computational Tools and Resources for LINCS Proteomics Data

Versatile, re-usable interfaces are required to facilitate integration of LINCS proteomics data into the tools and platforms being developed by the LINCS/BD2K community. Protein Line Notation or PLN Converter (http://eh3.uc.edu/pln) is developed to enable consistent mapping and annotation of peptide probes, including protein and pathway mapping, and harmonize proteomic data sets across different centers and assays. piLINCS (pilincs.org) has been designed to provide both interactive and API level access to reduced phosphoproteomic (P100) and global chromatin (GCP) pertubagen profiles generated by the Broad Institute and made available through Panorama, and as a basis for further integration of LINCS proteomic data.