Published June 26, 2026
| Version v1
Dataset
Open
Gut microbe-generated metabolite trimethylamine N-oxide and risk of abdominal aortic aneurysm: a cohort study
Authors/Creators
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Li, Xinmin S.
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Wang, Meng
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Wang, Zeneng
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Fan, Bingbing
- Tian, Melissa Y.
- Filippazzo, Jesse
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Lee, Yujin
- Mallela, Deepthi P
- Mao, Karis
- Liu, Yang
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Lemaitre, Rozenn N.
- Xie, Victor
- Diaz, Emilia
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DiDonato, Joseph A.
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Tang, W. H. Wilson
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de Oliveira Otto, Marcia C.
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Budoff, Matthew J
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Owens III, A Phillip
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Newman, Anne B.
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Cameron, Scott J
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Siscovick, David S
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Lusis, Aldons J
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Mozaffarian, Dariush
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Hazen, Stanley L
Description
In community-based older adults, higher circulating levels of the gut microbe-derived metabolite TMAO were independently associated with increased risk for AAA development and adverse AAA events including AAA surgical repair, AAA rupture, or AAA-related death. These findings support TMAO as a novel risk factor for AAA and adverse aortic outcomes and are consistent with the potential targeting of TMAO levels as treatment for AAA prevention.
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Additional details
Dates
- Accepted
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2026-06-26