THREE COMPONENT SYNTHESIS OF 4,4( ARYLMETHYLENE) BIS (1H-PYRAZOL- 5-OLS)

Pyrazoles have attracted particular attention due to the diverse biological activities associated with this heterocyclic system, and some have been shown to be cytotoxic to several human cell lines. Several drugs currently on the market have this heterocycle as the key structural motif, and some have been approved for the treatment of different types of cancer.