Published 2026 | Version v1

Shared striatal neurons exhibit context-specific dynamics for internally and externally driven actions

  • 1. New York University Grossman School of Medicine
  • 2. ROR icon Yale University
  • 3. ROR icon Allen Institute
  • 4. EDMO icon Columbia University

Description

Data set for: 
Shared striatal neurons exhibit context-specific dynamics for internally and externally driven actions. (2026)
Jan L. Klee, Sulekh Fernando-Peiris, Sahil Suresh, Ines Rodrigues-Vaz, Darcy S. Peterka, Rui M. Costa, Vivek R. Athalye, and Tanya Sippy

Science Advances. 10.1126/sciadv.aed9386

There are 2 files in this upload:

1. The file named "2026_Klee_ScienceAdv.pdf" is the Open Access pdf of the online publication in Science Advances.

2. The file named "Klee_ScienceAdv_data_code.zip" (~3.5 GB) is a zipped version of a folder ‘Klee_ScienceAdv_data_code’, which contains the data analyzed in the study along with the Matlab codes used to generate the published figures. To access the data and the codes, first unzip the file to access the following folders:

1. Data Structures: there are 7 data structures corresponding to the various data plotted in the  main and supplementary figures. See file readme_data_structure_contents for the definition/contents of each subfield.

2. Support Functions:

·         The folder “Matlab” contains MATLAB  support functions: these are support functions needed to run the codes. Set your path to add all subfolders of this folder in order to be able to run the code. add the folder with subfolders to the Matlab path and run the different codes. **

·         The “Bonsai” folder contains functions needed to import data from the data structures. Set your path to add all subfolders of this folder in order to be able to run the code.  Add the folder with subfolders to the Matlab path and run the different codes.

** For Figures 4, S6, S7, and S8, the parallel computing toolbox must be installed for it to run. You can find this within the toolboxes in Matlab.

3. Figure Functions: At the beginning of each Figure the code will require you to set a command directory to the structures folder to call the needed data structure for plotting. Edit this to wherever you have downloaded the structure. The code will plot each panel of each figure. 

  • ‘Figure1.m’: computers and plots the results for the panels B-J of Figure 1
  • ‘Figure2.m’: computes and plots the results for the panels C-H of Figure 2. 
  • ‘Figure3.m’: computes and plots the results for the panels B-J of Figure 3.
  • ‘Figure4.m’: computes and plots the results for the panels A-L of Figure 4. 
  • ‘FigureS1.m’: computes and plots the results for the panels B-Q of Figure S1. 
  • ‘FigureS2.m’: computes and plots the results for the panels A-H of Figure Ss. 
  • ‘FigureS3.m’: computes and plots the results for the panels A-D of Figure S3. 
  • ‘FigureS4.m’: computes and plots the results for the panels A-F of Figure S2. 
  • ‘FigureS5.m’: computes and plots the results for the panels A-E of Figure S5. 
  • ‘FigureS6.m’: computes and plots the results for the panels A-C of Figure S6. 
  • ‘FigureS7.m’: computes and plots the results for the panels A-L of Figure S7. 
  • ‘FigureS8.m’: computes and plots the results for the panels A-J of Figure S8. 

 

Files

Klee_ScienceAdv_data_code.zip

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Additional details

Related works

Cites
Publication: 10.1126/sciadv.aed9386 (DOI)

Funding

National Institutes of Health
Sensory Plasticity in the Auditory Striatum as an Impetus for Action Control R01NS126391
National Institutes of Health
Dissecting the Synaptic and Cellular Actions of Dopamine In Vivo R01MH130658
Whitehall Foundation
Research Project Grant 2021-12-091
Burroughs Wellcome Fund
Career Award for Medical Scientists 1018390
Deutsche Forschungsgemeinschaft
Walter Benjamin Fellowship

Software

Programming language
MATLAB

References

  • Shared striatal neurons exhibit context-specific dynamics for internally and externally driven actions. (2026) Jan L. Klee, Sulekh Fernando-Peiris, Sahil Suresh, Ines Rodrigues-Vaz, Darcy S. Peterka, Rui M. Costa, Vivek R. Athalye, and Tanya Sippy Science Advances. 10.1126/sciadv.aed9386