DEVELOPMENT AND CHARACTERIZATION OF GENTAMICIN TRANSFEROSOMAL GEL

The present study was focused on develop and evaluate Gentamicin containing transferosomes formulation for in vitro studies. Transferosomes formulations were prepared by using thin film hydration method and were evaluated for in vitro characteristics, stability studies. Transferosomes formulation displayed highest entrapment efficiency with desired particle size. SEM analyses showed that Transferosomes formulation was spherical in shape. Transferosomes containing lipid higher percentage of drug release after 12 h as compared to other formulations. F8 formulation was found to be stable at the end of the study on storage condition. The present study suggested that Transferosomes gel formulations provide sustained and prolonged delivery of drug with enhance bioavailability.

Keywords: Transferosomes, Gentamicin, bioavailability, thin film hydration method, In vitro drug release studies.