Estimation of exposure to dietary acrylamide based on mercapturic acid levels in urine (LC-MS)

We determined metabolites of acrylamide and glycidamide concentrations (AAMA and GAMA, respectively) in urine of 93 Polish women within the first days after delivery, using LC-MS/MS. The median AAMA and GAMA levels in urine were 20.9 μg/L (2.3 ÷ 399.0 μg/L) and 8.6 μg/L (1.3 ÷ 85.0 μg/L), respectively. In smokers we found significantly (p < 0.01) higher levels of metabolites in comparison with the non-smoking women.