Immunotherapy Response and Survival Outcome by Immunophenotypic Signature in Non-Small Cell Lung Cancer

Bansal, Dhruv; Ponvilawan, Ben; Grachev, Dmitrii; Kushnarev, Vladimir; Tarasov, Artem; Valiev, Ivan; Danilov, Konstantin; Butusova, Anna; Turova, Polina; Bagaev, Alexander; Kotlov, Nikita; Al-Obaidi, Ammar; Ward, Christopher; Subramanian, Janakiraman; BostonGene Corporation

doi:10.5281/zenodo.16098622

Published July 21, 2025 | Version v1

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Immunotherapy Response and Survival Outcome by Immunophenotypic Signature in Non-Small Cell Lung Cancer

1. St. Luke's Cancer Institute, University of Missouri–Kansas City School of Medicine, Kansas City, Missouri, USA
2. University of Missouri–Kansas City
3. BostonGene, Corp., Waltham, Massachusetts, USA
4. University of Kansas Medical Center
5. Inova Schar Cancer Institute, Fairfax, Virginia, USA

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License: Terms for provision of data to third parties - DATA ACCESS AGREEMENT

These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorized Personnel: The individuals at the User Institution to whom BostonGene Corporation grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorized Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: BostonGene Corporation and the collaborators listed in Appendix I responsible for the development, organization, and oversight of this Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. The User Institution also agrees that it will submit a report to the BostonGene Data Access Committee, if requested, on completion of the Research Purpose. The BostonGene Data Access Committee agrees to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User Institution. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. The User Institution understands and acknowledges that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out research with the Data, or sale of all or part of the Data on any media is not permitted. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorized Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the accuracy, comprehensiveness, further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognizing the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analyzing these Data. You agree to acknowledge in any such publication that the research makes use of Data generated by BostonGene Corporation. 9. You recognize that nothing in this Agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on the comparisons with their own data. Any invention or discovery made by User and/or User Institution arising out of the use of the Data (each a “Data Invention”) shall be promptly disclosed to BostonGene Corporation in writing. User Institution hereby grants to BostonGene Corporation a royalty-free, fully-paid, non-exclusive license (i) to make, use and import such Data Invention for internal research purposes; and (ii) to make, use, offer to sell, sell and import such Data Invention to the extent necessary to commercialize BostonGene Corporation product(s), which license shall be sublicensable to BostonGene Corporation’s affiliates and development and commercialization collaborators on such product(s). 10. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 11. The User Institution will notify BostonGene Corporation within 30 days of any changes or departures of Authorized Personnel. 12. The User Institution will notify BostonGene Corporation prior to any significant changes to the protocol for the Project. 13. The User Institution will notify BostonGene Corporation as soon as it becomes aware of a breach of the terms or conditions of this agreement. 14. BostonGene Corporation may terminate this agreement for convenience by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 15. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than BostonGene Corporation. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 16. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 17. The User Institution agrees to distribute a copy of these terms to the Authorized Personnel. The User Institution will procure that the Authorized Personnel comply with the terms of this agreement. 18. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of the Commonwealth of Massachusetts, United States. Nothing herein shall create any association, partnership, joint venture, fiduciary duty or the relation of principal and agent between the parties hereto, it being understood that each party is acting as an independent contractor, and neither party shall have the authority to bind the other or the other’s representatives in any way. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for BostonGene Corporation Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY APPENDIX I – DATASET DETAILS (to be completed by the data producer before passing to applicant) Dataset reference (Zenodo DOI ID and Dataset Details) Name of project that created the dataset Names of other data producers/collaborators Specific limitations on areas of research Minimum protection measures required File access: Data can be held in unencrypted files on an institutional computer system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., Zenodo DOI ID and Dataset Accession Number Brief abstract of the Project in which the Data will be used (500 words max) All Individuals who the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor* Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY BostonGene Corporation intends to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. BostonGene Corporation anticipates that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until 6 months after these data were first made available on the relevant hosting database, unless BostonGene Corporation has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database and its accession numbers, and acknowledge its use in a form agreed by the User Institution with BostonGene Corporation.

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Created: July 22, 2025
Modified: July 22, 2025

Immunotherapy Response and Survival Outcome by Immunophenotypic Signature in Non-Small Cell Lung Cancer

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