MXenes and MXene-based composites for biomedical applications

MXenes, a novel class of two-dimensional materials, have recently emerged as promising candidates for biomedical applications due to their specific structural features and exceptional physicochemical and biological properties. These materials, characterized by unique structural features and superior conductivity, have applications in tissue engineering, cancer detection and therapy, sensing, imaging, drug delivery, wound treatment, antimicrobial therapy, and medical implantation. Additionally, MXene-based composites, incorporating polymers, metals, carbon nanomaterials, and metal oxides, offer enhanced electroactive and mechanical properties, making them highly suitable for engineering electroactive organs such as the heart, skeletal muscle, and nerves. However, several challenges, including biocompatibility, functional stability, and scalable synthesis methods, remain critical for advancing their clinical use. This review comprehensively overviews MXenes and MXene-based composites, their synthesis, properties, and broad biomedical applications. Furthermore, it highlights the latest progress, ongoing challenges, and future perspectives, aiming to inspire innovative approaches to harnessing these versatile materials for next-generation medical solutions. © 2025 The Royal Society of Chemistry.