Supplimental Files

Table S1.xlsx: MR results for cis-mQTLs-PD. This includes effect estimates, confidence intervals, significance values, results of sensitivity analysis, Steiger, and colocalization analysis for causal inference; Table S2.xlsx: MR results for cis-eQTLs-PD. This includes effect estimates, confidence intervals, significance values, and results of sensitivity analysis, Steiger, and colocalization analysis for causal inference. Table S3.xlsx: MR results for cis-pQTLs-PD. This includes effect estimates, confidence intervals, significance values, and results of sensitivity analysis, Steiger, and colocalization analysis for causal inference; Table S4.xlsx: Gene tier results. Gene tier classification results, ranking genes based on their multi-omics evidence for causal associations with PD, were categorized into different confidence levels; Table S5.xlsx: Detailed information on the studies and datasets. Comprehensive details of the studies and datasets used in the analysis, including sample sizes, population characteristics, and data sources; Table S6.xlsx: Basic SNP information for cis-mQTLs-PD. Summary of SNPs associated with cis-mQTLs and PD, providing basic genetic variant information, including positions, effect alleles, allele frequencies, and statistical significance; Table S7.xlsx: Basic SNP information for cis-eQTLs-PD. Summary of SNPs associated with cis-eQTLs and PD, detailing genetic variant properties relevant to gene transcription regulation and PD risk; Table S8.xlsx: Basic SNP information for cis-pQTLs-PD. Summary of SNPs associated with cis-pQTLs and PD, listing key genetic variants influencing protein abundance and their association with PD.