BACLOFEN INDUCED ENCEPHALOPATHY – A Study of two cases with review of literature

Baclofen ,a centrally acting muscle relaxant is used for the treatment of spasticity,
muscle spasms and intractable hiccups. Its main route of excretion is urine , therefore
the drug gets accumulated in patients with chronic kidney disease resulting in toxicity.
We report two cases of chronic kidney disease who developed encephalopathy with
baclofen and improved after stopping the drug, spontaneously in the first patient and
after two sessions of dialysis in the second case.