A suitable microsurgical method for obstructive cholestasis in the rat

Obstructive cholestasis is characterized clinically by jaundice, discolored urine, pale stools and pruritus (1). The obstruction of the biliary tree, either intrahepatic or extrahepatic, causes a high rate of morbility and mortality in the human clinical field (2). The serious repercussions of cholestasis on the liver and on the systemic level (1,2) have led to the creation of many experimental surgical models so as to better understand its pathogenesis, prophylaxis, and treatment.