Published May 30, 2025
| Version v1
Book chapter
Open
Convolvulus pluricaulis: Traditional Use and Modern Scientific Insights
Authors/Creators
- 1. Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara-391760, Gujarat.
Description
Convolvulus pluricaulis, commonly known as Shankhpushpi, is a well-recognized ayurvedic herb belonging to the family Convolvulaceae, traditionally used to manage neurological and psychological ailments. This comprehensive review explores its botanical characteristics, cultivation practices, therapeutic uses, and pharmacological properties. Cultivated in semi-arid regions with minimal agronomic input, C. pluricaulis thrives in sandy soils under full sunlight. The plant exhibits a wide range of bioactivities including neuro-protective, antioxidant, anti-inflammatory, anxiolytic, antidepressant, antiepileptic, hepatoprotective, antimicrobial, and cardiovascular effects. Bioactive compounds such as convolamine, β-sitosterol, valeric acid, squalene, and ascorbic acid contribute to its pharmacological potential. Empirical data from various preclinical and clinical studies support its traditional use, particularly in managing anxiety, depression, cognitive dysfunction, and oxidative stress. This review underscores the need for further mechanistic and clinical studies to fully elucidate its therapeutic efficacy and safety profile.
Files
8. Kinjal P. Patel.pdf
Files
(457.2 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:4f4cb8baf83881308a7011e9e210b8c9
|
457.2 kB | Preview Download |
Additional details
References
- 1. Agarwa, P., Sharma, B., Fatima, A., & Jain, S. K. (2014). An update on Ayurvedic herb Convolvulus pluricaulis Choisy. Asian Pacific Journal of Tropical Biomedicine, 4(3), 245–252. 2. Mishra, S. H., & Sethiya, N. K. (2010). Review on ethnomedicinal uses and phytopharmacology of memory boosting herb Convolvulus pluricaulis Choisy. Australian Journal of Medical Herbalism, 22(1), 19–25 3. Bhowmik, D., Kumar, K. S., Paswan, S., Srivastava, S., & Dutta, A. (2012). Traditional Indian herbs Convolvulus pluricaulis and its medicinal importance. Journal of Pharmacognosy and Phytochemistry, 1(1), 44–51. 4. Rachitha, P., Krupashree, K., Jayashree, G. V., Kandikattu, H. K., Amruta, N., Gopalan, N., et al. (2018). Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis. Journal of Traditional and Complementary Medicine, 8(4), 483–496. 5. Verma, S., Sinha, R., Kumar, P., Amin, F., Jain, J., & Tanwar, S. (2012). Study of Convolvulus pluricaulis for antioxidant and anticonvulsant activity. Central Nervous System Agents in Medicinal Chemistry, 12(1), 55–59. 6. Yadav, S., Hemke, A., & Umekar, M. (2018). Convolvulaceae, a morning glory plant review. International Journal of Pharmaceutical Sciences Review and Research, 51(1), 103–117. 7. Jaiswal, R. K., Dikshit, M., Tiwari, R. C., Singh, A. K., & Sharma, V. B. (2023). A conceptual study of Convolvulus pluricaulis Choisy. World Journal of Pharmacy and Pharmaceutical Sciences, 8(10), 1046–1058. 8. Aparna, K., Prasad, D. X., Prabosh, G., Surbhi, G., & Franco, S. (2023). A review study on medicinal significance Convolvulus pluricaulis. i-Manager's Journal on Chemical Sciences, 3(3). 9. Ganie, S. H., Ali, Z., Das, S., Srivastava, P. S., & Sharma, M. P. (2015). Genetic diversity and chemical profiling of different populations of Convolvulus pluricaulis (Convolvulaceae): an important herb of Ayurvedic medicine. Biotech, 5, 295–302. 10. Khan, S., Kala, C., Goyal, M., Yadav, S. K., & Taleuzzaman, M. (2023). Evaluation of CNS depressant and anti-anxiety activities of leaves of Convolvulus pluricaulis. Central Nervous System Agents in Medicinal Chemistry, 23(1), 48–56. 11. Bihaqi, S. W., Sharma, M., Singh, A. P., & Tiwari, M. (2009). Neuroprotective role of Convolvulus pluricaulis on aluminium-induced neurotoxicity in rat brain. Journal of Ethnopharmacology, 124(3), 409–415. 12. Iyer, D., Jain, N., & Patil, U. K. (2023). Antihyperlipidemic bioactivity guided isolation and structural elucidation of isolated phytoconstituents from Convolvulus pluricaulis Choisy. European Journal of Medicinal Plants, 34(11–12), 81–91. 13. Irshad, S., Ali, M. A., Makbul, S. A., & Shamsi, S. (2024). Effect of Convolvulus pluricaulis (Shankhpushpi) and Bacopa monnieri (Brahmi) on aging-related diseases and memory deficits. In Medicinal Plants for the Management of Neurodegenerative Diseases (pp. 85–98). 14. Sharma, K., Arora, V., Rana, A. C., & Bhatnagar, M. (2009). Anxiolytic effect of Convolvulus pluricaulis Choisy petals on elevated plus maze model of anxiety in mice. Journal of Herbal Medicine and Toxicology, 3(1), 41–46. 15. Sharma, R., Singla, R. K., Banerjee, S., Sinha, B., Shen, B., & Sharma, R. (2022). Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies. Neuroscience & Biobehavioral Reviews, 140, 104795. 16. Gupta, G. L., & Fernandes, J. (2019). Protective effect of Convolvulus pluricaulis against neuroinflammation-associated depressive behavior induced by chronic unpredictable mild stress in rat. Biomedicine & Pharmacotherapy, 109, 1698–1708. 17. Amin, H., Sharma, R., Vyas, M., Prajapati, P. K., & Dhiman, K. (2014). Shankhapushpi (Convolvulus pluricaulis): Validation of the Ayurvedic therapeutic claims through contemporary studies. International Journal of Green Pharmacy, 8(4). 18. Ravichandra, V. D., Ramesh, C., & Sridhar, K. A. (2013). Hepatoprotective potentials of aqueous extract of Convolvulus pluricaulis against thioacetamide-induced liver damage in rats. Biomedicine & Aging Pathology, 3(3), 131–135. 19. Mudgal, V. (1975). Studies on medicinal properties of Convolvulus pluricaulis and Boerhaavia diffusa. Planta Medica, 28(5), 62–68. 20. Somarathinam, K., Gunalan, S., Sailapathi, A., Pannerselvam, B., Mohanasundari, M., Balaraman, A. K., et al. (2023). Antihypertensive effects of pentacyclic triterpenoid from Convolvulus pluricaulis and its plausible mechanism of action hypothesizing its selectivity targeting mineralocorticoid receptor of RAAS. Phytomedicine Plus, 3(1), 100408. 21. Melloni, E., Grassilli, S., Romani, A., Rimondi, E., Marcuzzi, A., Zauli, E., et al. (2023). Convolvulus pluricaulis Choisy's extraction, chemical characterization and evaluation of the potential effects on glycaemic balance in a 3T3-L1 adipocyte cell model. Nutrients, 15(7), 1727. 22. Verma, A. K., & Dubey, G. P. (2011). Effect of Convolvulus pluricaulis and triflupromazine on rat brain and blood biogenic amines. Research Journal of Pharmacy and Technology, 4(4), 549–551. 23. Irshad, S., Ali, M. A., Makbul, S. A. A., & Shamsi, S. (2024). Effect of Convolvulus pluricaulis (Shankhpushpi) and Bacopa Monnieri (Brahmi) on aging-related diseases and memory deficits. Medicinal Plants for the Management of Neurodegenerative Diseases, 85-98. 24. Perera, P. K., Meedeniya, A. C., & Chamikara, N. H. (2021). Traditional medicinal plants of Sri Lanka and their derivatives of benefit to the nervous system. In Medicinal Herbs and Fungi: Neurotoxicity vs. Neuroprotection (pp. 315–346). 25. Sharma, M., Sahu, S., Khemani, N., & Kaur, R. (2013). Ayurvedic medicinal plants as psychotherapeutic agents: A review. International Journal of Applied Biology and Pharmaceutical Technology, 9(2), 214–218. 26. Singh, U. P., Singh, N. P., Murphy, E. A., Price, R. L., Fayad, R., Nagarkatti, M., & Nagarkatti, P. S. (2016). Chemokine and cytokine levels in inflammatory bowel disease patients. Cytokine, 77, 44–49. 27. Guimbaud, R., Bertrand, V., Chauvelot-Moachon, L., Quartier, G., Vidon, N., Giroud, J. P., et al. (1998). Network of inflammatory cytokines and correlation with disease activity in ulcerative colitis. American Journal of Gastroenterology, 93(12), 2397–2404.