Role of ANT2 in mitochondrial function and cancer cell survival: a target for therapeutic intervention
- 1. Institute of Biotechnology, Czech Academy of Sciences, Prague, Czechia.
- 2. Institut klinicke a experimentalni mediciny
Description
In summary, ANT2 is an important component of the mitochondrial machinery in PDAC cancer cells, which could be targeted pharmacologically. This warrants further investigation into the biological role of ANT2 in PDAC. Furthermore, our findings of potentiated effect between ANT2 disruption and OXPHOS inhibition by MitoTam suggest that this combination offers a potentially novel approach for therapeutic targeting of PDAC tumors (see Suppl. Fig. 3 for scheme). As current ANT inhibitors suffer from low specificity/efficacy (e.g. Suramin) [14] or high toxicity (CATR), our results provide a rationale for developing new, more specific ANT2 inhibitors for use in PDAC.
Notes
Supported by the project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, ID Project No. LX22NPO5104) - Funded by the European Union – Next Generation EU.
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s41420-025-02510-z.pdf
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- 40335504 (PMID)
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- 2058-7716 (ISSN)
- References
- 10.1038/s41420-025-02510-z (DOI)