A Comprehensive Review of Cryptolepis buchananii R.Br. ex Roem. & Schult.

Cryptolepis buchananii R.Br. ex Roem. & Schult., a woody climber belonging 
to the family Apocynaceae, is increasing scientific attention for its rich 
ethnomedicinal properties and broad-spectrum pharmacological activities. 
The plant has been extensively used to treat skin disorders, fever, 
inflammation, rickets, and blood impurities. Recent phytochemical 
investigations have led to the isolation of several bioactive compounds, 
including alkaloids, glycosides, and a novel proteolytic enzyme named 
cryptolepain. Pharmacological studies have demonstrated significant anti
inflammatory, analgesic, chondroprotective, antioxidant, and hypoglycemic 
activities. Botanical description of the plant with local names, bioactive 
compounds and pharmacological properties are described in detail.