Published May 8, 2025 | Version v1
Journal article Open

The role of non-invasive brain stimulation (NIBS) in post-stroke motor recovery: synergies with antihypertensive therapy

Authors/Creators

  • 1. assistant of the department of clinical laboratory diagnostics with the course of Clinical laboratory diagnostics of the faculty of postgraduate education.
  • 2. Doctor of Philosophy in Medical Sciences (PhD), Assistant Professor, Department of Pathological Physiology, Samarkand State Medical University, Uzbekistan
  • 3. DSc, associate professor of the department of Children Diseases, Pediatrics. Tashkent Medical Academy,
  • 4. DSc, associate professor of the Department of Faculty and Hospital Surgery. Bukhara State Medical Institute named after Abu Ali ibn Sino. Bukhara, Uzbekistan
  • 5. assistance of the Department of Faculty and Hospital Therapy of the Bukhara State Medical Institute named after Abu Ali ibn Sino. Bukhara, Uzbekistan
  • 6. PhD, Senior teacher of the Department of Hygiene No.2 of the Bukhara State Medical Institute Named After Abu Ali Ibn Sino. Uzbekistan
  • 7. Head of the Department of Pediatrics, Candidate of Medical Sciences, Associate Professor of the Fergana Medical Institute of Public Health, Republic of Uzbekistan. Ferghana.

Description

Stroke is one of the leading causes of motor disability worldwide, further emphasizing the need for novel strategies in rehabilitation. In this research, the authors investigate the role of non-invasive brain stimulation (NIBS) in the recovery of motor function following stroke and coordination with antihypertensive therapy in an integrated system. The present study will be a randomized clinical trial in the selected hospitals of Uzbekistan and will examine the additive effect of NIBS techniques (i.e., TMS and tDCS) and antihypertensive treatment on improving motor function, neuroplasticity, and blood pressure control. The major hypothesis is that using both these two strategies in combination will markedly increase the effectiveness of rehabilitation through increasing the neuronal mechanisms and cerebral blood flow. This research will use clinical assessment, electrophysiological observation, and neuroimaging to gather the data and analyze it with the help of sophisticated statistical analysis. The results of this study should provide a complete system of individualized post-stroke rehabilitation protocols in different groups, especially the Central Asian population.

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