Bulgarian Neurology
Published November 30, 2024 | Version v1
Journal article Open

Polyneuropathy, organomegaly, endocrinopathy, m protein and skin changes syndrome (POEMS) – literature review

Authors/Creators

  • 1. UMHAT Sofiamed
  • 2. ROR icon Sofia University "St. Kliment Ohridski"

Description

Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome (POEMS) is a rare paraneoplastic syndrome, associated with plasma cell dyscrasia. POEMS involves several clinical signs and symptoms with varying presentation. The first and most prominent of them is the subacute painful sensory and motor polyneuropathy. The diagnosis is based on Dispenzieri criteria (2017). Differential diagnosis involves chronic demyelinating polyneuropathy, amyloidosis, monoclonal gammopathy of undetermined significance, chronic hepatitis, Humman Immunodeficiency Virus and other paraneoplastic syndromes. The treatment is interdisciplinary.

Abstract (Bulgarian)

Синдромът на полиневропатия, органомегалия, eндокринопатия, М-протеин и кожни промени (POEMS) е рядък паранеопластичен синдром, обвързан с плазмоклетъчна дискразия.
Характеризира се с няколко клинични симптома с различна честотата на разпространение, от които водещ и първи е субакутната болезнена сензомоторна полиневропатия. Диагнозата се поставя на база критериите на Dispenzieri от 2017 год. Диференциалната диагноза включва хронична демиелинизираща полиневропатия, амилоидоза, моноклонална гамапатия с неясно значение, хронични хепатити, Human immunodeficiency virus и други паранеопластични синдроми. Лечението е комплексно и изисква тясна колаборация между невролог, хематолог и интернист.

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Additional details

Additional titles

Translated title (Bulgarian)
Синдром на полиневропатия, органомегалия, едрокринопатия, м-протеин и кожни промени (POEMS) – литературен обзор

Identifiers

ARK
ark:/53357/NEU.v26iS1.172
URL
https://www.nevrologiabg.com/journal/index.php/neurology/article/view/172
ISSN
2815-2522

Dates

Issued
2024-11-30

References

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