Synthesis and Biological Evolution of Derivatives of Thiosemicarbazide

We have in the present study, the pharmacological properties of derivatives of thiosemicarbazide, synthesis of substituted 1-(1-(6- methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl) ethylidene) thiosemicarbazide are carried out by refluxing 5-acetyl-6-methyl-4-phenyl- 3,4-dihydropyrimidin-2(1H)-one and thiosemicarbazide in equimolar ratio in the presence of alcohol, acetic acid. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, Mass spectral and Elemental analysis. These compounds were screened for anti- bacterial, anti-fungal and antioxidant activities. Antimicrobial activities of the compounds were also determined at different levels of concentration. Most of the synthesized compounds exhibited mild to moderate anti-bacterial, anti-fungal and antioxidant activities.