Case of Pure Mucinous Breast Carcinoma: A Rare Entity
Authors/Creators
- 1. International Journal of Medical Science and Innovative Research (IJMSIR)
Description
Pure mucinous breast carcinoma is a rare subtype of invasive breast cancer characterized by the production of extracellular mucin. It typically demonstrates a distinctive histological appearance, higher hormone receptor positivity, and favorable clinical outcomes, with a good response to endocrine therapy. This case highlights the importance of recognizing pure mucinous carcinoma as a distinct pathological entity for optimal management and prognosis.
Summary
Pure mucinous breast carcinoma is a rare subtype of invasive breast cancer characterized by the production of extracellular mucin. It has a distinctive histological appearance, fewer chances of lymph node involvement, higher hormone receptor positivity, favourable clinical outcome, and good response to endocrine treatment. We report one such case in a 52-year-old female having a left breast mass of approximately 5 months duration with no nodal involvement. USG showed a hyperechoic lesion measuring 26 x 21 x 27 mm. FNAC showed mild to moderate pleomorphic epithelial cells with a moderate amount of mucin and ‘chicken wire’ blood vessels. Histopathology of the resected specimen showed clusters of tumour cells floating in pools of abundant extracellular mucin partitioned by fibrous septa containing blood vessels. Immunohistochemistry revealed ER and PR positivity and Her-2 Neu was negative. 6-month follow-up CT scan showed no recurrence. This case underscores the significance of recognizing this subtype as a distinct clinical entity.
Files
HEMA.pdf
Additional details
Software
References
- 1. Tseng HS, Lin C, Chan SE, et al. Pure mucinous carcinoma of the breast: clinicopathologic characteristics and long-term outcome among Taiwanese women. World J Surg Oncol 2013;11:139 2. Bae SY, Choi MY, Cho DH, Lee JE, Nam SJ, Yang JH. Mucinous carcinoma of the breast in comparison with invasive ductal carcinoma: clinicopathologic characteristics and prognosis. J Breast Cancer 2011;14(4):308–313 3. Lei L, Yu X, Chen B, Chen Z, Wang X. Clinicopathological characteristics of mucinous breast cancer: a retrospective analysis of a 10-year study. PLoS One 2016;11(5):e0155132 4. Wen HY, Desmedt, Reis-Filho JS, Schmitt F. Mucinous carcinoma. In: Allison KH, Brogo E, Ellis IO, Fox S, Morris E, Sahin A, editors. WHO Classification of Tumours, Breast Tumours. 5th ed. Lyon: International Agency for Research on Cancer; 2019. P. 123-5. 5. Chikkannaiah P, Thangngeo D, Guruprasad C, Venkataramanappa S. Clinicopathological Study of Mucinous Carcinoma of Breast with Emphasis on Cytological Features: A Study at Tertiary Care Teaching Hospital of South India. J Lab Physicians. 2020 Mar;12(1):68-75. 6. Di Saverio S, Gutierrez J, Avisar E. A retrospective review with long term follow up of 11,400 cases of pure mucinous breast carcinoma. Breast Cancer Res Treat. 2008 Oct;111(3):541-7. 7. Hamid S, Mudassar M, Tariq H, Hameed S, Mehmood T, Tariq S. Clinicopathological characteristics of mucinous carcinoma of the breast. Professional Med J 2024; 31(05):704-711. 8. Wang, H., Hu, Y., Tan, C. et al. Differential diagnosis of breast mucinous carcinoma with an oval shape from fibroadenoma based on ultrasonographic features. BMC Women's Health 2024;24: 87. 9. Dang BQ, Miles B, Young P, He J, Nguyen QD. Mucocele-Like Lesion of the Breast. Cureus. 2023 Apr 19;15(4):e37829. 10. Fencer MG, Abghari M, Eladoumikdachi F, Kowzun MJ. Rare Presentation of Pure Mucinous Carcinoma of the Breast: HER2-positive Subtype in a Premenopausal Woman. ACS Case Reviews in Surgery. 2023;4(2):45-49.