Published April 11, 2025 | Version v0.0.1

African LD files for GhostKnockoffGWAS

Authors/Creators

  • 1. ROR icon Stanford University

Description

This contains pre-processed LD files (Sigma matrix, S matrix, ...etc) computed on African samples of the UK-Biobank (n = 5951). It is intended to be used as an input to the GhostKnockoffGWAS pipeline

  • This is the output of applying solveblock executable directly on 3394 African samples of the UK-Biobank.
  • Quasi-independent blocks are computed by applying the snp_ldsplit function with parameters thr_r2=0.01, max_r2=0.3, min_size = 500, and max_size = {1000, 1500, 3000, 6000, 10000}. 
  • SNPs with minor allele frequency less than 0.01 or Hardy-Weinburg equilibrium p-value less than 1e-6 are removed. 
  • Only HG19 coordinates are available. 
  • Knockoff optimization were carried out by the Knockoffs.jl julia package: https://github.com/biona001/Knockoffs.jl
  • The result (i.e. files available in this site) is saved in .csv and .h5 formatted files for easier access, which is directly readable by GhostKnockoffGWAS

Files

AFR.zip

Files (7.7 GB)

Name Size
md5:23f55b58f7dad86f2cbd7350006a87df
7.7 GB Preview Download

Additional details

Dates

Available
2025-04-11