Published April 3, 2025 | Version v1

Female summary statistics from "Role of X chromosome and dosage compensation mechanisms in complex trait genetics"

  • 1. ROR icon Institute for Molecular Medicine Finland

Description

Full female summary statistics generated in "Role of X chromosome and dosage compensation mechanisms in complex trait genetics". 

For UK biobank (UKB), GWAS were performed using BOLT-LMM v2.3.2. The files contain the following columns:

  • SNP: rs number or ID string
  • CHR: chromosome
  • BP: base pair position mapped to assembly GRCh37
  • GENPOS: genetic position either from bim file or interpolated from genetic map
  • ALLELE1: first allele in bim file (usually the minor allele), used as the effect allele
  • ALLELE0: second allele in bim file, used as the reference allele
  • A1FREQ: frequency of first allele
  • F_MISS: frequency of first allele
  • CHISQ_LINREG: standard linear regression chi-square statistics
  • P_LINREG: standard linear regression p-value
  • BETA: effect size from BOLT-LMM approximation to infinitesimal mixed model
  • SE: standard error of effect size
  • CHISQ_BOLT_LMM_INF: infinitesimal mixed model association test chi-square statistics
  • P_BOLT_LMM_INF: infinitesimal mixed model association test p-value
  • CHISQ_BOLT_LMM: non-infinitesimal mixed model association test chi-square statistics
  • P_BOLT_LMM: non-infinitesimal mixed model association test p-value

For FinnGen R10 (FG), GWAS were performed using REGENIE v2.2.4 pipeline. The files contain the following columns:

  • #chrom: chromosome
  • pos: base pair position mapped to assembly GRCh38
  • ref: reference allele
  • alt: alternative allele
  • pval: analysis p-value
  • mlogp: -log10(p-value)
  • beta: effect size of alternate allele
  • sebeta: standard error of effect size
  • af_alt: allele frequency of the alternative allele

Files

Files (39.6 GB)

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