Published November 21, 2025 | Version v0.2.0
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PHILHARMONIC Results for P. damicornis, C. goreaui, and D. melanogaster

  • 1. ROR icon Flatiron Institute
  • 2. ROR icon Massachusetts Institute of Technology

Description

PHILHARMONIC is a novel computational approach that couples deep learning de novo network inference with robust unsupervised spectral clustering algorithms to uncover functional relationships and high-level organization in non-model organisms. Our clustering approach allows us to de-noise the predicted network, producing highly informative functional modules.

We apply PHILHARMONIC to predict clusters with significant functional coherence in the reef-building coral P. damicornis and its algal symbiont C. goreaui, and the well-annotated fruit fly D. melanogaster.

Files

pdamicornis_human_readable.txt

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Additional details

Related works

Is part of
Preprint: 10.1101/2024.10.25.620267 (DOI)

Software

Repository URL
https://github.com/samsledje/philharmonic
Programming language
Python