Published April 7, 2025
| Version v1
Journal article
Open
GUIDE: A prospective case-control study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing
Authors/Creators
- Ao, Huang1
- De-Zhen, Guo1
- Zhixi, Su2
- Yun-Shi, Zhong3
- Liang, Liu4
- Zhi-Guo, Xiong5
- Dong-Li, He6, 7
- Bin, Yan8
- Quan-Lin, Li3
- Zhen, Feng6, 7
- Wen-Quan, Wang4
- Pin-Xiang, Lu9
- Meng-Jiang, He3
- Zhi-Peng, Qi3
- Qi, Guo7
- Jian-Wen, Cheng1
- Shi-Yu, Zhang1
- Wei, Guo10
- Qing, Li11
- Guo-Yong, Lin12
- Hui-Chuan, Sun1
- Shuang-Jian, Qiu1
- Qi-Ye, He2
- Jia, Fan1
- Ajay, Goel13, 14
- Rui, Liu (Project leader)2
- Gang, Jin (Project leader)15
- Xin-Rong, Yang (Project leader)1
- Jian, Zhou (Project leader)1
- 1. Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai 200032, China
- 2. Singlera Genomics (Shanghai) Ltd., Shanghai 201203, China
- 3. Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- 4. Department of Pancreatic Surgery, Cancer Center, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- 5. Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, China
- 6. Department of Gastroenterology, Xuhui Central Hospital, Zhongshan Hospital, Fudan University, Shanghai 200031, China
- 7. Endoscopy Center, Xuhui Central Hospital, Zhongshan Hospital, Fudan University, Shanghai 200031, China
- 8. Department of Clinical Laboratory, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, China
- 9. Department of General Surgery, Xuhui Central Hospital, Shanghai 20031, China
- 10. Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- 11. Xiangya Medical Laboratory, Central South University, Changsha 410078, China
- 12. Department of Respiratory and Critical Illness Medicine, the First Hospital of Putian, Putian 351100, China
- 13. Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, Monrovia, CA, USA
- 14. City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
- 15. Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Navy Medical University (the Second Military Medical University), Shanghai 200433, China
Description
Supplementary Data
- training_data.csv
- validation_data.csv
- independant_test_data.csv
- data_description.txt
- train_cn.py
- train_too.py
- inference.py
- Code_README.txt
Files
Code_README.txt
Files
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