THE DRUG PHYSIOTENS, THE FEATURES OF THE DRUG AND ITS USE IN THE FIELD OF CARDIOLOGY, IN PATIENTS WITH HEAVY BODY WEIGHT

Moxonidine (Fisiotens®) is an antihypertensive drug that selectively interacts with imidazoline I1-receptors located in the brainstem, resulting in a decrease in sympathetic activity and blood pressure (BP). Moxonidine (Fisiotens®) has high affinity to imidazoline I1 -receptors and only slightly binds to central α2 -adrenoreceptors, due to interaction with which dry mouth and sedative effect are mediated; reduces tissue resistance to insulin. Decrease in systolic and diastolic BP at a single and prolonged administration of the drug is associated with a decrease in the pressor action of the sympathetic nervous system on peripheral vessels, reduction of total peripheral resistance (TPR).