BRAINscape
Authors/Creators
-
1.
Columbia University Irving Medical Center
Description
BRAINscape: A Comprehensive Multi-Omics Analysis Tool
Overview
BRAINscape is an R package designed for integrative multi-omics analysis, specifically developed for the MU-BRAIN dataset, a multiethnic RNAseq dataset. The package facilitates stratified eQTL mapping and Differential Expression Analysis, providing a user-friendly framework for researchers to explore genetic and transcriptomic associations.
Features
- eQTL Analysis: Supports cis and trans eQTL mapping.
- Differential Expression Analysis: Uses DESeq2 for robust transcriptomic profiling.
- Interactive Data Exploration: Shiny-based web interface for data visualization.
- Supports Ethnicity-Specific Analysis: Users can filter results by Hispanic and Non-Hispanic Whites (NHW) groups.
- Advanced Visualization:
- Manhattan Plots for eQTL results.
- Volcano Plots for Differential Expression Analysis.
Files
Restricted
The record is publicly accessible, but files are restricted. <a href="https://zenodo.org/account/settings/login?next=https://zenodo.org/records/14925129">Log in</a> to check if you have access.
Additional details
Software
- Repository URL
- https://github.com/vivekruhela/BRAINscape
- Programming language
- R
- Development Status
- Active
References
- Yang, Z., Cieza, B., Reyes-Dumeyer, D., Lee, A., Ma, Y., Yilmaz, E., Lantigua, R., Miller, G.W., Brown, L.M., Honig, L. and Ciener, B., 2024. MU-BRAIN: MUltiethnic Brain Rna-seq for Alzheimer INitiative. bioRxiv, pp.2024-02.