Crystallization of Cryptophane-A and Cryptophane-A Derivatives with and without Encapsulated Guests

Detailed protocols for crystallizing cryptophane-guest complexes are provided. Cryptophane molecular cages (cryptophane-A, also tripropargyl and triallyl derivatives) were crystallized with water, xenon, methanol, or without guest via the vapor diffusion method and with chloroform via slow evaporation. The average time required to grow cryptophane crystals is 1 week.