Synthesis and Antioxidant Study Of 4-(1- Benzofuran-2-Yl)-1,3-Thiazole-2-Amine and its Derivatives

Salicylaldehyde upon treatment with bromoacetone in presence of anhydrous potassium carbonate give 2-acetylbenzofuran. (III) This 2-acetylbenzzofuran after bromination give bromoacetylbenzofuran. (IV). This bromoacetylbenzofuran on treatment with thiourea in ethanol gives 4 (1-benzofuran-2-yl)1,3-thiazole -2-amine. (V)  The corresponding compound (V) on treatment with various aldehydes to give different derivative (VI). The characterization of synthesized compounds was identified o the basis of IR, NMR, MASS and elementary analysis. The compound has been   evaluated for anti-bacterial, anti-inflammatory, and analgesic activity. The present study is focused on the development of new potent bioactive molecule with less toxic, safer and easy available. Modern therapeutic is based on scientific observation supported by systematic assessment of activity of drug is simulated and clinical condition. The integrity of the drug molecule, optimization Antioxidant properties of drug from the dosage.