Single-Cell and Spatial Omics in Liver Identify Cell-Cell Communication Regulators in Aging and Insulin Resistance

Single-cell RNA-seq, ATAC-seq, and Spatial Transcriptomics (Resolve BioSciences' Molecular Cartography) of the Mouse Liver in Aging and Insulin Resistance

liver_spatial.rds: Seurat object including processed data for all samples, for Spatial Transcriptomics

liver_scRNAseq.rds: Seurat object including processed data for all samples, for scRNA-seq data

liver_scATAC.rds: Seurat object including processed data for all samples, for scATAC-seq data

*.txt: coordinates for all target molecules detected; Unit: 138 nm/pixel

*.tiff: DAPI images

Sample information for Spatial Transcriptomics: 

A1, B2: Young;

A2, C1: Old insulin sensitive;

B1, C2: Old insulin resistant.