Published 2013
| Version v1
Journal article
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Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity
Authors/Creators
- Zhang, Guojie
- Cowled, Christopher
- Shi, Zhengli
- Huang, Zhiyong
- Bishop-Lilly, Kimberly A.
- Fang, Xiaodong
- Wynne, James W.
- Xiong, Zhiqiang
- Baker, Michelle L.
- Zhao, Wei
- Tachedjian, Mary
- Zhu, Yabing
- Zhou, Peng
- Jiang, Xuanting
- Ng, Justin
- Yang, Lan
- Wu, Lijun
- Xiao, Jin
- Feng, Yue
- Chen, Yuanxin
- Sun, Xiaoqing
- Zhang, Yong
- Marsh, Glenn A.
- Crameri, Gary
- Broder, Christopher C.
- Frey, Kenneth G.
- Wang, Lin-Fa
- Wang, Jun
Description
(Uploaded by Plazi for the Bat Literature Project) Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola and SARS. To identify genetic changes associated with the development of bat-specific traits, we performed whole genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropusalectoand insectivorous Myotisdavidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and NF-κBpathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.
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Additional details
Identifiers
- URL
- hash://md5/82704d9e2df0700df92848339008b96f
- URN
- urn:lsid:zotero.org:groups:5435545:items:9JQYTZN9
- DOI
- 10.1126/science.1230835
Biodiversity
- Kingdom
- Animalia
- Phylum
- Chordata
- Class
- Mammalia
- Order
- Chiroptera