Published April 24, 2019
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Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation
Authors/Creators
- 1. Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas
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2.
Centro de Edafología y Biología Aplicada del Segura
- 3. CEBAS-CSIC
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4.
Consejo Superior de Investigaciones Científicas
Description
Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity. We describe here for the first time the tissue deconjugation of Uro-A glur to Uro-A after lipopolysaccharide (LPS)-induced inflammation, which could explain the systemic in vivo activity of free Uro-A in microenvironments subjected to inflammatory stimuli.
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2019_Articulo 023 Urolithin-A deconjugation.pdf
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Additional details
Funding
- Consejo Superior de Investigaciones Científicas
- Polifenoles de la dieta frenta al cáncer de mama: Estudios metabólicos y moleculares; Estudio POLYSEN 201770E081
- Ministerio de Ciencia, Innovación y Universidades
- Elagitaninos de la dieta como herramienta para estudiar la variabilidad interindividual en el metabolismo de polifenoles AGL2015-64124-R