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Published March 10, 2025 | Version v1
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Cortical synaptic vulnerabilities revealed in an alpha-synuclein aggregation model of Parkinson's disease: Dataset for excitatory and inhibitory synaptic loci analysis

Authors/Creators

  • 1. ROR icon Yale University

Contributors

  • 1. ROR icon Yale University
  • 2. ROR icon University of Alabama at Birmingham
  • 3. ROR icon University of Pennsylvania
  • 4. ROR icon Van Andel Institute
  • 5. Washington University School of Medicine in St. Louis

Description

Tabular data for following experiments:

  1. pSyn pathology negatively impacts excitatory transmission: Electrophysiology data obtained from cortical slices. 
  2. pSyn_progression__analysis_1MPI_3MPI_6MPI_SS: Microscopic data for pSyn analysis over 1month, 3 month, 6 month post-injection
  3. SEQUIN Dataset 1_3_6 MPI_Synaptic loci Frequency_Distribution_Density_SS: Excitatory and inhibitory synaptic loci quantification. 
  4. syngo_annotations_NeunEnriched_DP: SynGO dataset
  5. syngo_annotations_pSynEnriched_DP: SynGO dataset
  6. Electron Microscopy analysis of Excitatory synapses
  7. pSyn pathology impact on synaptic density_pSyn and synapse loss corelation_AS: Analysis of synaptic localization of pSYN, synaptic density, and association of synaptic pSYN to pSYN positive neurites was quantified

Files

Electron Microscopy analysis of Excitatory synapses_JR_DR.zip

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Additional details

Funding

Aligning Science Across Parkinson's
Understanding and Manipulating Cellular and Circuit-Level Vulnerability to Neurodegeneration in Parkinson’s disease 020616