Published July 18, 2024 | Version v1
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The Potential of Crocus sativus in the treatment of Burns—mini Review

  • 1. Mustansiriyah University, College of Pharmacy,Department of Pharmacognosy and Medicinal Plants.

Contributors

  • 1. Mustansiriyah University, College of Pharmacy ,Department of Pharmacognosy and Medicinal Plants.

Description

This article under review  summarizes clinical and animal model studies that prove the potential of ingredients of saffron including safranal, crocetin and crocins  extracts and their admixtures in treating of burn wound because of treating of burns still a receive attention in contemporary medicine, notably in developing nations that cannot supply costly and  progressive medicines.Reviews presented in databases such as Google Scholar,Scopus,Pub-Med,Web of Science and Science Direct, published in English in 2008–2022,were considered.According to medical trials which described, it was shown that saffran extracts have notable effectiveness in treating of burn wounds, including reducing inflammation and speeding up the healing process than the conventional treatment used hitherto. This current review emphasis on the aspect of the main active comounds of  saffron, on healing  burn and  the mechanisms investigated by researchers in treating. Researches on animal pattern indications that saffran preparation may have potential beneficial in the treatment burn wounds.According to antibacterial activity,mechanism of action, low toxicity and mild cost, saffran extracts can compete with conventional treatment. 

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References

  • Dumville, J. C., C. Munson and J. Christie, 2014. Negative pressure wound therapy for partial‐thickness burns. Cochrane Database of Systematic Reviews.
  • Singer, A. J. and R. A. Clark, 1999. Cutaneous wound healing. New England journal of medicine, 341, 738-746.
  • Deveci, M., M. Eski, M. Sengezer and U. Kisa, 2000. Effects of cerium nitrate bathing and prompt burn wound excision on IL-6 and TNF-α levels in burned rats. Burns, 26, 41-45.
  • Kumar, B., M. Vijayakumar, R. Govindarajan and P. Pushpangadan, 2007. Ethnopharmacological approaches to wound healing—exploring medicinal plants of India. Journal of ethnopharmacology, 114, 103-113.
  • Thakur, R., N. Jain, R. Pathak and S. S. Sandhu, 2011. Practices in wound healing studies of plants. Evidence-based complementary and alternative medicine, 2011.
  • Al-Azzawi, M. A., Maftool, A. J., Al-Shimary, A. A., & Mohammed, A. A. (2023). A Comprehensive Review of Vitamin D3: Metabolism, Functions, and Clinical Implications. International Journal of Medical Science and Dental Health, 9(12), 37-46.
  • Niroumand, M. C., M. H. Farzaei, E. K. Razkenari, G. Amin, M. Khanavi, T. Akbarzadeh and M. R. Shams-Ardekani, 2016. An evidence-based review on medicinal plants used as insecticide and insect repellent in traditional Iranian medicine. Iranian Red Crescent Medical Journal, 18.
  • Bahramsoltani, R., M. H. Farzaei and R. Rahimi, 2014. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Archives of dermatological research, 306, 601-617
  • Melnyk JP, Wang SN, Marcone MF. 2010. Chemical and biological properties of the world's most expensive spice saffron. Food Res Int 43: 1981–1989
  • Gavali, L. V., Mohammed, A. A., Al-Ogaili, M. J., Gaikwad, S. H., Kulkarni, M., Das, R., & Ubale, P. A. (2024). Novel terephthalaldehyde bis (thiosemicarbazone) Schiff base ligand and its transition metal complexes as antibacterial Agents: Synthesis, characterization and biological investigations. Results in Chemistry, 7, 101316.
  • Bathaie SZ, Mousavi SZ. 2010. New applications and mechanisms of action of saffron and its important ingrdients. Crit Rev Food Sci Nutr 50: 761–86
  • Ghaffari, S. and N. Roshanravan, 2019. Saffron; An updated review on biological properties with special focus on cardiovascular effects. Biomedicine & Pharmacotherapy, 109, 21-27.
  • Christodoulou, E., N. P. Kadoglou, N. Kostomitsopoulos and G. Valsami, 2015. Saffron: a natural product with potential pharmaceutical applications. Journal of Pharmacy and Pharmacology, 67, 1634-1649.
  • Rameshrad, M., B. M. Razavi and H. Hosseinzadeh, 2018. Saffron and its derivatives, crocin, crocetin and safranal: a patent review. Expert opinion on therapeutic patents, 28, 147-165.
  • Dadkhah, M.; Ehtesham, M.; Fekrat, H. ëIranian Sa_ron an Unknown Jewelí, 1st ed.; Shahr Ashub Publication:Tehran, Iran, 2003.
  • Moghaddasi, M.S. Sa_ron chemicals and medicine usage. J. Med. Plants Res. 2010, 4, 427–430.
  • Mahmoud, H. Q., Mhana, R. S., & Mohammed, A. A. (2024). Therapeutic options and management approach on thalassemia an overview. International Journal of Medical Science and Dental Health, 10(01), 17-28.
  • Ha, H., J. Park, Y. S. Kim and H. Endou, 2004. Oxidative stress and chronic allograft nephropathy. Yonsei Medical Journal, 45, 1049-1052.
  • Flessas, I. I., A. E. Papalois, K. Toutouzas, F. Zagouri and G. C. Zografos, 2011. Effects of lazaroids on intestinal ischemia and reperfusion injury in experimental models. Journal of Surgical Research, 166, 265-274.
  • Katada, K., A. Bihari, S. Mizuguchi, N. Yoshida, T. Yoshikawa, D. D. Fraser, R. F. Potter and G. Cepinskas, 2010. Carbon monoxide liberated from CO-releasing molecule (CORM-2) attenuates ischemia/reperfusion (I/R)-induced inflammation in the small intestine. Inflammation, 33, 92-100.
  • Comino-Sanz, I. M., M. D. López-Franco, B. Castro and P. L. Pancorbo-Hidalgo, 2021. The role of antioxidants on wound healing: A review of the current evidence. Journal of clinical medicine, 10, 3558.
  • Zhou, C., W. Bai, Q. Chen, Z. Xu, X. Zhu, A. Wen and X. Yang, 2015. Protective effect of crocetin against burn-induced intestinal injury. journal of surgical research, 198, 99-107.
  • Alemzadeh, E. and A. Oryan, 2018. Effectiveness of a Crocus sativus extract on burn wounds in rats. Planta medica, 84, 1191-1200
  • Khorasani, G., S. J. Hosseinimehr, P. Zamani, M. Ghasemi and A. Ahmadi, 2008. The effect of saffron (Crocus sativus) extract for healing of second-degree burn wounds in rats. The Keio journal of medicine, 57, 190-195.
  • Burak Ozdemir, M., M. Burcin Piskin, M. Bahar Gok, N. Demir and Y. Budama‐Kilinc, 2021. Fabrication and Characterization of Saffron Stamen Aqueous Extract Controlled Release System as Potential Topical Treatment of Thermal Burn Wounds. ChemistrySelect, 6, 6579-6585.
  • Schmidt M, Betti G, Hensel A. 2007. Saffron in phytotherapy: pharmacology and clinical uses. Wien Med Wochenschr 157: 315–319.
  • Schmidt M, Betti G, Hensel A. 2007. Saffron in phytotherapy: pharmacology and clinical uses. Wien Med Wochenschr 157: 315–319.