HMGCR enzyme deficiency model in mice

HMGCR enzyme deficiency model in mice is used in the mitoHMGCR project to study the physiological role of HMGCR enzyme and molecular mechanisms of  statin-induced side effects.The specific objectives of the mitoHMGCR project cover delineation of detrimental effects of HMGCR deficiency in the tissue-specific KO mice models (liver and brain astrocyte), identification of biochemical markers, and therapeutic target pathways to treat HMGCR deficiency-induced sequels such as hepatotoxicity, myopathy, and neurological deficits, creation of new models and tools for testing HMGCR-targeted strategies. Collected data include metabolic phenotyping and mitochondrial functionality measures. Energy metabolite levels were analyzed in tissue and blood samples from a mice model of HMGCR enzyme KO. Transcriptomics data provide information regarding the involved signalling pathways.