Published October 30, 2015
| Version v1
Journal article
Open
Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1
Authors/Creators
- Vacchelli, Erika1
- Ma, Yuting1
- Baracco, Elisa E.2
- Sistigu, Antonella3
- Enot, David P.4
- Pietrocola, Federico2
- Yang, Heng1
- Adjemian, Sandy5
- Chaba, Kariman6
- Semeraro, Michaela7
- Signore, Michele8
- De Ninno, Adele9
- Lucarini, Valeria8
- Peschiaroli, Francesca8
- Businaro, Luca9
- Gerardino, Annamaria9
- Manic, Gwenola3
- Ulas, Thomas10
- Günther, Patrick10
- Schultze, Joachim L.10
- Kepp, Oliver1
- Stoll, Gautier1
- Lefebvre, Céline11
- Mulot, Claire12
- Castoldi, Francesca13
- Rusakiewicz, Sylvie7
- Ladoire, Sylvain14
- Apetoh, Lionel14
- Bravo-San Pedro, José Manuel1
- Lucattelli, Monica15
- Delarasse, Cécile16
- Boige, Valérie17
- Ducreux, Michel18
- Delaloge, Suzette19
- Borg, Christophe20
- André, Fabrice21
- Schiavoni, Giovanna8
- Vitale, Ilio22
- Laurent-Puig, Pierre23
- Mattei, Fabrizio8
- Zitvogel, Laurence24
- Kroemer, Guido1
- 1. Gustave Roussy Cancer Campus, Villejuif, France.; INSERM, U1138, Paris, France.; Équipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.; Université Pierre et Marie Curie, Paris, France.
- 2. Gustave Roussy Cancer Campus, Villejuif, France.; INSERM, U1138, Paris, France.; Équipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.; Faculté de Médecine, Université Paris-Saclay, Kremlin-Bicêtre, France.
- 3. Regina Elena National Cancer Institute, Rome, Italy.
- 4. Gustave Roussy Cancer Campus, Villejuif, France.; INSERM, U1138, Paris, France.; Équipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
- 5. Gustave Roussy Cancer Campus, Villejuif, France.; INSERM, U1138, Paris, France.; Équipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.
- 6. Gustave Roussy Cancer Campus, Villejuif, France.; INSERM, U1138, Paris, France.; Équipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
- 7. Gustave Roussy Cancer Campus, Villejuif, France.; INSERM, U1015, Villejuif, France.; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France.
- 8. Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
- 9. Italian National Research Council, Institute for Photonics and Nanotechnology, Rome, Italy.
- 10. Genomics and Immunoregulation, Life and Medical Science Center Institute, University of Bonn, Germany.
- 11. Gustave Roussy Cancer Campus, Villejuif, France.; INSERM, U981, Villejuif, France.
- 12. Université Paris Sorbonne Cité, UMRS 775, INSERM, Paris, France.; INSERM U1147, Centre de Ressources Biologiques (CRB) EPIGENETIC, Paris, France.
- 13. Gustave Roussy Cancer Campus, Villejuif, France.; INSERM, U1138, Paris, France.; Équipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.; Faculté de Médecine, Université Paris-Saclay, Kremlin-Bicêtre, France.; Sotio, Prague, Czech Republic.
- 14. Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France.; Université Bourgogne Franche-Comté, Dijon, France.; Centre Georges François Leclerc, Dijon, France.
- 15. Department of Life Sciences, University of Siena, Siena, Italy.
- 16. Institut du Cerveau et de la Moelle Épinière, ICM CNRS UMR 7225 – INSERM U 1127 – UPMC-P6 UMR S 1127, Équipe Neurogénétique et Physiologie Hôpital de la Pitié-Salpêtrière, 47, Boulevard de l'Hôpital, 75013 Paris, France.
- 17. INSERM U1147, Centre de Ressources Biologiques (CRB) EPIGENETIC, Paris, France.; Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif Cedex, France.
- 18. Faculté de Médecine, Université Paris-Saclay, Kremlin-Bicêtre, France.; Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif Cedex, France.
- 19. INSERM, U981, Villejuif, France.; Department of Breast Oncology, Gustave Roussy Cancer Campus, Villejuif, France.
- 20. University of Franche-Comté, INSERM 1098, France.
- 21. Gustave Roussy Cancer Campus, Villejuif, France.; INSERM, U981, Villejuif, France.; Department of Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France.; Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France.
- 22. Regina Elena National Cancer Institute, Rome, Italy.; Department of Biology, University of Rome "Tor Vergata," Rome, Italy.
- 23. Université Paris Sorbonne Cité, UMRS 775, INSERM, Paris, France.; INSERM U1147, Centre de Ressources Biologiques (CRB) EPIGENETIC, Paris, France.; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
- 24. Gustave Roussy Cancer Campus, Villejuif, France.; Faculté de Médecine, Université Paris-Saclay, Kremlin-Bicêtre, France.; INSERM, U1015, Villejuif, France.; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France.
Description
How dying tumor cells get noticed
Besides killing tumor cells directly, some chemotherapies, such as anthracyclines, also activate the immune system to kill tumors. Vacchelli
et al.
discovered that in mice, anthracycline-induced antitumor immunity requires immune cells to express the protein formyl peptide receptor 1 (FPR1). Dendritic cells (DCs) near tumors expressed especially high amounts of FPR1. DCs normally capture fragments of dying tumor cells and use them to activate nearby T cells to kill tumors, but DCs lacking FPR1 failed to do this effectively. Individuals with breast or colon cancer expressing a variant of FPR1 and treated with anthracyclines showed poor metastasis-free and overall survival. Thus, FPR1 may affect anti-tumor immunity in people, too.
Science
, this issue p.
972
Files
fulltext.pdf
Files
(1.4 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:1cf0e24e8081f2a5881e5cbf6ac286f9
|
1.4 MB | Preview Download |