Published June 17, 2016
| Version 5
Dataset
Open
Human Histone Deacetylase 6 (HDAC6); A Target Enabling Package
Description
HDAC6 is a cytosolic deacetylase with diverse roles in cellular trafficking, autophagy and cell signalling. Specifically targeting the unique zinc-finger ubiquitin-binding domain (ZnF-UBD) of HDAC6 may be an attractive strategy in myeloma and lymphoma but no inhibitor has been reported to date. Presented here are 4 co-crystal structures of HDAC6 ZnF-UBD in complex with different compounds, and associated SPR, ITC and FP assays.
Notes
This document represents version 5 of the TEP datasheet and includes all updates on the project as of October 2018. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.
Files
HDAC6_TEP_datasheet_v5.pdf
Files
(1.6 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:766ec618278994457a078fb6671821de
|
1.6 MB | Preview Download |
Additional details
Related works
- Is part of
- https://www.thesgc.org/tep (URL)