Data and code from: Distinct transmission sites within a synapse for strengthening and homeostasis
- 1. University of Pittsburgh
- 2. European Neuroscience Institute Göttingen
- 3. Universitätsmedizin Göttingen
Description
We used patch-clamp electrophysiology from mouse brain slices to record miniature excitatory postsynaptic currents (mEPSC), evoked EPSCs, and EPSCs with two-photon glutamate uncaging at single spines (uEPSC) to determine the synaptic properties in visual cortex layer 2/3 pyramidal neurons during development from postnatal day (P) 10 until P30. Different parameters of the synaptic responses, such as amplitude, half-width, and frequency of mEPSCs were determined. These data and their analysis are documented in the Excel file Data_for_Figures. We also constructed a synaptic model to explain our results. The model for silent synapses is documented in the Excel file SS_simulation. The synaptic model was developed in MatLab, and the code is included in the file Figure_7_code. The fitting of the mEPSC amplitude distribution is documented in the file Figure_4_code.
Notes
Funding provided by: National Institute of Mental Health
ROR ID: https://ror.org/04xeg9z08
Award Number: MH131717
Files
Figure_4_code.zip
Additional details
Related works
- Is source of
- 10.5061/dryad.7pvmcvf3x (DOI)