Expanding kinetoplastid genome annotation through protein structure comparison

Description

This table is the result of applying the ASC pipeline to all protein sequences available in TriTrypDB release 65, representing 84 genomes. It is a summarized version of what is referred to in the article as the "Final Dataset."

Metadata: Column Names and Descriptions

• TriTrypsDB_Organism: Name of the genome in TriTrypDB (Trypanosoma brucei brucei TREU927, Leishmania major Friedlin 2021, Trypanosoma cruzi Dm28c 2018, )
• TriTrypsDB_GeneID: Gene ID corresponding to the TriTrypDB genome.
• TriTrypDB_Product Description: Description of gene product in TriTrypDB.
• TriTrypDB_Gene Name or Symbol: Gene name or symbol in TriTrypDB.
• TriTrypDB_Ortholog Group: Ortholog group assigned in TriTrypDB.
• kineto_cluster_representer: Gene ID of the cluster representative.
• query_uniprot_accession: UniProt accession of the structure representing the cluster.
• query_uniprot_accession_pLDDT_mean: Mean pLDDT score of the structure representing the cluster.
• target_uniprot_accession: UniProt accession of the structure obtained from SRBH for the reference organism.
• Reference_Organism: Name of the reference organism.
• proteome: Proteome of the reference organism.
• alnlen/fident/evalue: SRBH data reported by Foldseek.
• TM-score_Chain1/TM-score_Chain2: SRBH data reported by FATCAT (top 5 results).
• Protein names/Gene Names/Taxonomic lineage/EC number/Function [CC]/Pathway/Gene Ontology (biological process)/Gene Ontology (cellular component)/Gene Ontology (GO)/Gene Ontology (molecular function)/Gene Ontology IDs/Protein families/KEGG/OrthoDB/eggNOG/PANTHER/InterPro/Pfam: Annotation data for the target UniProt accession.