Published October 21, 2021
| Version v1
Journal article
Open
Nanodelivery Systems Face Challenges and Limitations in Bone Diseases Management
Authors/Creators
- 1. Center for Musculoskeletal Regeneration Houston Methodist Academic Institute, Houston Methodist 6670 Bertner Ave Houston TX 77030 USA; Orthopedics and Sports Medicine Houston Methodist Hospital Houston Methodist, 6565 Fannin Street Houston TX 77030 USA
- 2. Center for Musculoskeletal Regeneration Houston Methodist Academic Institute, Houston Methodist 6670 Bertner Ave Houston TX 77030 USA; Orthopedics and Sports Medicine Houston Methodist Hospital Houston Methodist, 6565 Fannin Street Houston TX 77030 USA; First Surgical Clinic Section, Department of Surgical Oncological and Gastroenterological Sciences, University of Padua Padua 35124 Italy; Nano‐Inspired Biomedicine Laboratory Institute of Pediatric Research—Città della Speranza Padua Italy
- 3. Center for Musculoskeletal Regeneration Houston Methodist Academic Institute, Houston Methodist 6670 Bertner Ave Houston TX 77030 USA; Orthopedics and Sports Medicine Houston Methodist Hospital Houston Methodist, 6565 Fannin Street Houston TX 77030 USA; Texas A&M College of Medicine 8447 Highway 47 Bryan TX 77807 USA
- 4. Section of Experimental Medicine, Department of Medical Sciences, School of Medicine University of Ferrara Ferrara Italy
- 5. First Surgical Clinic Section, Department of Surgical Oncological and Gastroenterological Sciences, University of Padua Padua 35124 Italy; Nano‐Inspired Biomedicine Laboratory Institute of Pediatric Research—Città della Speranza Padua Italy
- 6. Texas Children's Cancer and Hematology Centers and The Faris D. Virani Ewing Sarcoma Center Baylor College of Medicine Houston TX 77030 USA
Description
AbstractBone is a highly dynamic tissue. Hence, diseases affecting bone tissue, such as cancer (primary tumors and metastases), osteoporosis, and genetic conditions present many challenges for traditional therapies, leading to poor therapeutic outcome. Nano‐delivery systems are innovative tools used for the treatment of a variety of diseases due to their ability to deliver various therapeutic cargos and specifically target disease sites, including difficult ones like bone. A variety of nano‐delivery strategies are recently explored to treat bone‐related pathologies, with many resulting in better outcomes than traditional approaches. In this review, the authors cover recent attempts to use nano‐delivery systems for the treatment of skeletal‐related disorders including primary bone tumors, metastatic bone tumors, and non‐cancerous bone disorders. Finally, potential barriers for the translation of such new therapeutics into the clinic and possible methods to overcome these barriers, are discussed.