SIB Swiss Institute of Bioinformatics - Biodata Resources
Published December 10, 2024 | Version v1
Dataset Open

neXtProt cancer variants portal

Creators

  • 1. ROR icon SIB Swiss Institute of Bioinformatics
  • 2. ROR icon Sophia Genetics (Switzerland)

Description

This portal provides information about the functional impact of genetic variants and artificially generated mutants in human proteins involved in cancer. Annotation statements are triplets composed of (1) a subject, which corresponds to the protein variant being annotated; (2) a relation describing how the property is affected, and (3) an object that describes the function, localization, or protein property being tested.

Files

Caloha_readme.txt.txt

Files (12.2 MB)

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Additional details

Funding

Krebsforschung Schweiz
KFS-3297-08-2013

References

  • Cusin I, Teixeira D, Zahn-Zabal M, Rech de Laval V, Gleizes A, Viassolo V, Chappuis PO, Hutter P, Bairoch A, Gaudet P. A new bioinformatics tool to help assess the significance of BRCA1 variants. Hum Genomics. 2018 Jul 11;12(1):36. doi: 10.1186/s40246-018-0168-0.
  • Gaudet P, Michel PA, Zahn-Zabal M, Britan A, Cusin I, Domagalski M, Duek PD, Gateau A, Gleizes A, Hinard V, Rech de Laval V, Lin JJ, Nikitin F, Schaeffer M, Teixeira D, Lane L, Bairoch A. The neXtProt knowledgebase on human proteins: 2017 update. Nucl. Acids Res. 2017 Jan 4;45(D1):D177-D182.