Human HSPC single cell RNA-seq data and analysis : Sickle Cell Disease gene therapy

The present repository contains the Single cell RNA-seq pipeline and data analysis, adapted from https://doi.org/10.5281/zenodo.7377739 by DENIS Adeline, CORTAL Akira, MARTIGNETTI Loredana, SIX Emmanuelle, RAUSELL Antonio.

The present repository is related to the following manuscript entitled

"Severe inflammation and lineage skewing are associated with poor engraftment of engineered hematopoietic stem cells in patients with sickle cell disease" 

by Steicy Sobrino, Laure Joseph, Elisa Magrin, Anne Chalumeau, Nicolas Hebert, Alice Corsia, Adeline Denis, Cécile Roudaut, Clotilde Aussel, Olivia Leblanc, Mégane Brusson, Tristan Felix, Jean-Sebastien Diana, Angelina Petrichenko, Jana El Etri, Auria Godard, Eden Tibi, Sandra Manceau, Jean Marc Treluyer, Fulvio Mavilio, Frederic D. Bushman, Ambroise Marcais, Martin Castelle, Benedicte Neven, Olivier Hermine, Sylvain Renolleau, Alessandra Magnani, Vahid Asnafi, Wassim El Nemer, Pablo Bartolucci, Emmanuelle Six, Michaela Semeraro, Annarita Miccio, Marina Cavazzana.