3D BIOPRINTING OF ARTIFICIAL MENISCUS WITH TUNABLE MECHANICAL PROPERTIES

Meniscal injuries are prevalent in orthopedics, often leading to compromised knee function and increased osteoarthritis risk. This study develops a hybrid bioink for 3D bioprinting artificial menisci with tunable mechanical properties, addressing the limitations of traditional repair methods. Through rheological analysis, tensile, and compression testing, the research identifies an optimal bioink composition of 50% polycaprolactone (PCL), 10% gelatin methacrylate (GelMA), and 7% sodium alginate (SA). This formulation achieves a favorable balance of mechanical strength and swelling behavior, closely mimicking the native meniscus. Specifically, the bioink provides sufficient stiffness to support structural integrity and elasticity to absorb impact, while also maintaining superior swelling properties to simulate the hydration and load-bearing characteristics of natural meniscus tissue. The findings highlight the potential of 3D bioprinted menisci in orthopedic applications, offering a promising approach for personalized meniscus repair and advancing regenerative medicine.