Platelet Count and Platelet Indices in Neonatal Sepsis
Authors/Creators
- 1. Assistant Professor, Department of Paediatrics, Surabhi Institute of Medical Sciences, Siddipet, Telangana
- 2. Assistant Civil Surgeon, Department of Dermatology, Venereology & Leprosy, District Hospital, Jagityal, Telangana
Description
Background: Neonatal sepsis is a significant cause of morbidity and mortality in newborns, particularly in low-resource settings. Early and accurate diagnosis is crucial for improving outcomes, but clinical signs are often non-specific. Platelet count and platelet indices, such as mean platelet volume (MPV) and platelet distribution width (PDW), have been suggested as potential biomarkers for neonatal sepsis. Aim and Objectives: This study aimed to evaluate the role of platelet count and platelet indices (MPV and PDW) as diagnostic markers in neonatal sepsis. Materials and Methods: A prospective observational study was conducted in the NICU of a tertiary care hospital in South India. The study included 50 neonates with clinical features of sepsis. Platelet count, MPV, and PDW were measured and compared between sepsis cases and a control group of non-septic neonates. Statistical analysis was performed to assess the significance of differences in these parameters between the two groups. Results: The study found that neonates with confirmed sepsis had significantly lower platelet counts and higher MPV and PDW compared to the control group (p<0.05). Thrombocytopenia was observed in 66% of the sepsis cases. MPV was elevated in 62% of sepsis cases, and PDW was increased in 68% of cases. These findings suggest a strong association between altered platelet indices and the incidence of neonatal sepsis. Conclusion: Platelet count and platelet indices, particularly MPV and PDW, are significant predictors of neonatal sepsis and can be valuable diagnostic tools in NICU settings. Their routine assessment may facilitate earlier diagnosis and targeted treatment, especially in resource-limited settings.
Abstract (English)
Background: Neonatal sepsis is a significant cause of morbidity and mortality in newborns, particularly in low-resource settings. Early and accurate diagnosis is crucial for improving outcomes, but clinical signs are often non-specific. Platelet count and platelet indices, such as mean platelet volume (MPV) and platelet distribution width (PDW), have been suggested as potential biomarkers for neonatal sepsis. Aim and Objectives: This study aimed to evaluate the role of platelet count and platelet indices (MPV and PDW) as diagnostic markers in neonatal sepsis. Materials and Methods: A prospective observational study was conducted in the NICU of a tertiary care hospital in South India. The study included 50 neonates with clinical features of sepsis. Platelet count, MPV, and PDW were measured and compared between sepsis cases and a control group of non-septic neonates. Statistical analysis was performed to assess the significance of differences in these parameters between the two groups. Results: The study found that neonates with confirmed sepsis had significantly lower platelet counts and higher MPV and PDW compared to the control group (p<0.05). Thrombocytopenia was observed in 66% of the sepsis cases. MPV was elevated in 62% of sepsis cases, and PDW was increased in 68% of cases. These findings suggest a strong association between altered platelet indices and the incidence of neonatal sepsis. Conclusion: Platelet count and platelet indices, particularly MPV and PDW, are significant predictors of neonatal sepsis and can be valuable diagnostic tools in NICU settings. Their routine assessment may facilitate earlier diagnosis and targeted treatment, especially in resource-limited settings.
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IJTPR,Vol14,Issue9,Article4.pdf
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Additional details
Dates
- Accepted
-
2024-08-26
Software
References
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