BaTiO3 nanocrystals with tunable exposed{001} polarfacets:A high-performance piezocataly stand piezoelectric regenerative medicine

Piezocatalysistriggeredbyultrasonicvibrationhasemergedasaneffectivestrategytoaddressthewidespread environmental challenges andhumanhealthconcerns.Nevertheless, thepursuit of high-performancepiezoelectricsthatcansimultaneouslyrealizecatalysisandbiotherapystillposesasignificantchallenge.Herein,we report anotableenhancement inpiezocatalyticperformanceofBaTiO3nanoplates featuringhighlyexposed {001}facets.Bycontrollingtheexposureofpolarfacets,BaTiO3withhighly{001}facets(I{001}/I{110}=4.17) exhibitsanimpressive1500%improvement indegradationefficiencycomparedtoBaTiO3withless-exposed {001} facets (I{001}/I{110} =0.76). Through in vitro ultrasonic stimulation, BaTiO3 also demonstrates a remarkableabilitytoregenerateneurons, facilitatingtherapiddifferentiationofneuralprogenitorcells into mature neurons. Themechanismof howpolar facets enhance the piezocatalytic activity is systematically investigatedbyfinite elementmethod (FEM) simulationanddensity functional theory (DFT) calculations, revealingthat theenhancement stems fromtheabundantactivesitesandstrongchargetransferability.This studythusoffersacomprehensiveunderstandingof therelationshipbetweenpolar facetsandpiezocatalytic performance, alsoproviding inspirationfor thedevelopment ofhigh-performancepiezoelectricmedicine for nerverepair.