Correlation between Glycemic Control and Diabetic Dermopathy Severity in Type 2 Diabetes Mellitus: A Cross-Sectional Study
- 1. Assistant Professor, Department of General Medicine, Mahaveer Institute of Medical Science and Research, Bhopal, Madhya Pradesh, India
- 2. Assistant Professor, Department of Dermatology, Venereology & Leprosy, Mahaveer Institute of Medical Science and Research, Bhopal, Madhya Pradesh, India
Description
Background: Diabetic dermopathy (DD) is a common cutaneous manifestation of diabetes mellitus (DM), characterized by atrophic, hyperpigmented lesions, primarily on the lower extremities. Chronic hyperglycemia, microangiopathy, and impaired wound healing are thought to contribute to the pathogenesis of DD. Aim and Objectives: To investigate the correlation between glycemic control, as measured by HbA1c levels, and the severity of diabetic dermopathy in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: A cross-sectional observational study was conducted with 150 patients diagnosed with T2DM. Demographic and clinical data, including HbA1c levels, were collected. Based on the number and size of lesions, the severity of DD was classified into mild, moderate, and severe categories. Statistical analyses were performed using Pearson’s correlation and ANOVA to assess the correlation between HbA1c levels and DD severity. Results: The mean age of the participants was 58.3 ± 8.9 years, and the average HbA1c level was 8.4 ± 1.2%. DD severity was categorized as mild in 38.7% of patients, moderate in 43.3%, and severe in 18.0%. A significant positive correlation was observed between HbA1c levels and DD severity (r = 0.68, p < 0.001). Patients with severe DD had a higher mean HbA1c (9.2 ± 1.1%) than those with mild DD (7.6 ± 0.8%). Additionally, patients with severe DD were more likely to have other microvascular complications, such as neuropathy and retinopathy. Conclusion: This study found a strong correlation between higher HbA1c levels and increased severity of diabetic dermopathy. Poor glycemic control was associated with more severe manifestations of DD, suggesting that tighter glucose management could mitigate the progression of skin complications in patients with diabetes.
Abstract (English)
Background: Diabetic dermopathy (DD) is a common cutaneous manifestation of diabetes mellitus (DM), characterized by atrophic, hyperpigmented lesions, primarily on the lower extremities. Chronic hyperglycemia, microangiopathy, and impaired wound healing are thought to contribute to the pathogenesis of DD. Aim and Objectives: To investigate the correlation between glycemic control, as measured by HbA1c levels, and the severity of diabetic dermopathy in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: A cross-sectional observational study was conducted with 150 patients diagnosed with T2DM. Demographic and clinical data, including HbA1c levels, were collected. Based on the number and size of lesions, the severity of DD was classified into mild, moderate, and severe categories. Statistical analyses were performed using Pearson’s correlation and ANOVA to assess the correlation between HbA1c levels and DD severity. Results: The mean age of the participants was 58.3 ± 8.9 years, and the average HbA1c level was 8.4 ± 1.2%. DD severity was categorized as mild in 38.7% of patients, moderate in 43.3%, and severe in 18.0%. A significant positive correlation was observed between HbA1c levels and DD severity (r = 0.68, p < 0.001). Patients with severe DD had a higher mean HbA1c (9.2 ± 1.1%) than those with mild DD (7.6 ± 0.8%). Additionally, patients with severe DD were more likely to have other microvascular complications, such as neuropathy and retinopathy. Conclusion: This study found a strong correlation between higher HbA1c levels and increased severity of diabetic dermopathy. Poor glycemic control was associated with more severe manifestations of DD, suggesting that tighter glucose management could mitigate the progression of skin complications in patients with diabetes.
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Additional details
Dates
- Accepted
-
2024-09-25
Software
- Repository URL
- http://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue10,Article92.pdf
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- Active
References
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