Impairment of Social Cognition among Patients with Epilepsy: A CrossSectional Analytical Study in a Tertiary Care Center
Authors/Creators
- 1. Senior Resident, Department of Neurology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu
- 2. Professor and HOD, Department of Neurology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu
- 3. Assistant Professor, Department of Neurology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu
Description
Introduction: Social cognition is defined as one’s ability to perceive and understand other people’s thoughts, feelings, and behaviour and to respond appropriately. Many neurological disorders affecting the brain leads to disruption in social cognitive function. Many studies which were done among people with epilepsy showed impairment in social cognition, which in turn resulted in impaired quality of life, employability, and other cognitive functions especially in PWE with temporal lobe (TLE) and extratemporal (ETE) epilepsies. Identifying the nature and magnitude of social cognitive impairment in people with epilepsy has both theoretical and clinical implications, including the potential to form guidelines for clinical assessment and psychosocial intervention. Methodology: Patient more than 18-year-old with epilepsy and who are stable on antiseizure medication (ASM) were included in the study after taking consent. The quality of life of PWE was assessed using the 31-item Quality of Life in Epilepsy inventory (QOLIE-31 translated to local language) QOLIE31. Measures of social cognition include tests of emotion recognition (ER) and the assessment of theory of mind (ToM). Three cognitive tests were used to measure the patients’ ability to understand human emotion and behavior. Results: It was observed that those persons with epilepsy performed worse on ToM task compared to healthy controls. The performance of ToM task among different types of epilepsy was similar. There was significant negative association between ToM tasks and duration of epilepsy and number of antiseizure medication used. The overall quality of life and social function was better in patients who scored more in RMET (Reading of the Mind in the Eyes test) and FPRT (Faux Pas Recognition Test) tasks. Conclusion: Social cognition is significantly affected by seizure especially when the duration of seizure and number of ASM increases. Overall quality of life is also affected when there is impairment in social cognition. The study shows that a higher performance score in ToM tasks may not be essential to be in a good relationship.
Abstract (English)
Introduction: Social cognition is defined as one’s ability to perceive and understand other people’s thoughts, feelings, and behaviour and to respond appropriately. Many neurological disorders affecting the brain leads to disruption in social cognitive function. Many studies which were done among people with epilepsy showed impairment in social cognition, which in turn resulted in impaired quality of life, employability, and other cognitive functions especially in PWE with temporal lobe (TLE) and extratemporal (ETE) epilepsies. Identifying the nature and magnitude of social cognitive impairment in people with epilepsy has both theoretical and clinical implications, including the potential to form guidelines for clinical assessment and psychosocial intervention. Methodology: Patient more than 18-year-old with epilepsy and who are stable on antiseizure medication (ASM) were included in the study after taking consent. The quality of life of PWE was assessed using the 31-item Quality of Life in Epilepsy inventory (QOLIE-31 translated to local language) QOLIE31. Measures of social cognition include tests of emotion recognition (ER) and the assessment of theory of mind (ToM). Three cognitive tests were used to measure the patients’ ability to understand human emotion and behavior. Results: It was observed that those persons with epilepsy performed worse on ToM task compared to healthy controls. The performance of ToM task among different types of epilepsy was similar. There was significant negative association between ToM tasks and duration of epilepsy and number of antiseizure medication used. The overall quality of life and social function was better in patients who scored more in RMET (Reading of the Mind in the Eyes test) and FPRT (Faux Pas Recognition Test) tasks. Conclusion: Social cognition is significantly affected by seizure especially when the duration of seizure and number of ASM increases. Overall quality of life is also affected when there is impairment in social cognition. The study shows that a higher performance score in ToM tasks may not be essential to be in a good relationship.
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IJPCR,Vol16,Issue10,Article66.pdf
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Additional details
Dates
- Accepted
-
2024-09-26
Software
- Repository URL
- http://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue10,Article66.pdf
- Development Status
- Active
References
- 1. M Ziaei, C Arnold, K Thompson, D C Reutens Social Cognition in Temporal and Frontal Lobe Epilepsy: Systematic review, Metaanalysis, and Clinical Recommendations. J Int Neuropsychol Soc. 2023 Feb; 29(2):205-229. 2. C D Frith .The social brain? Philos Trans R Soc Lond B Biol Sic. 2007 Apr 29; 362(1480):671-8. 3. M Arioli, C Crespi, N Canessa .Social Cognition through the Lens of Cognitive and Clinical Neuroscience. Biomed Res Int. 2018 Sep 13:2018:4283427:1-18. 4. A Farrant, R G Morris, T Russell, R Elwes, N Akanuma, G Alarcón, M Koutroumanidis. Social cognition in frontal lobe epilepsy.Epilepsy Behav. 2005 Nov; 7(3):506-16. 5. Guida, M.; Caciagli, L; Cosottini, M.; Bonuccelli, U.; Fornai, F.; Giorgi, F.S. Social cognition in idiopathic generalized epilepsies and potential neuroanatomical correlates. Epilepsy Behav. 2019, 100, 106118. 6. Morou, N.; Papaliagkas, V.; Markouli, E.; Karagianni, M.; Nazlidou, E.; Spilioti, M.; Afrantou, T.; Kimiskidis, V.K.; Foroglou, N.;Kosmidis, M. Theory of Mind impairment in focal versus generalized epilepsy. Epilepsy Behav. 2018, 88, 244–250. 7. Bora, E.; Meletti, S. Social cognition in temporal lobe epilepsy: A systematic review and meta-analysis. Epilepsy Behav. 2016, 60, 50– 57. 8. Realmuto, S.; Zummo, L.; Cerami, C.; Agrò, L.; Dodich, A.; Canessa, N.; Zizzo, A.; Fierro, B.; Daniele, O. Social cognition dysfunctions in patients with epilepsy: Evidence from patients with temporal lobe and idiopathic generalized epilepsies:Epilepsy Behav. 2015, 47, 98–103 9. A Jasionis, K Puteikis, R Mameniškienė. The Impact of Social Cognition on the Real-Life of People with Epilepsy:Brain Sci.2021 Jun 30;11(7):877 10. Devinsky, K J Meador,J A Cramer, B P Hermann, R D Hays,K R Perrine, B G Vickrey:Quality of life in epilepsy QOLIE-31 (version -1) scoring manual:1993:1-8 11. S Baron-Cohen , S Wheelwright, J Hill, Y Raste, I Plumb .The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism: J Child Psychol Psychiatry. 2001 Feb; 42(2):241-51. 12. Russell J. Chander, Sarah A. Grainger, John D. Crawford, Karen A. Mather, Katya Numbers, Rhiagh Cleary, Nicole A. Kochan, Henry Brodaty, Julie D. Henry, Perminder S. Sachdev Development of a short-form version of the Reading the Mind in the Eyes Test for assessing theory of mind in older adults.J Inter Geriatric Psychiatry.2020 Nov;35(11):1322- 1330. 13. J Negrão, H T Akiba, V R G Lederman, Á M Dias.Faux Pas Test in schizophrenic patients. J. bras. psiquiatr. 65 (1) • Jan-Mar 2016; 18-21 14. Stone, V.E., Baron-Cohen, S. & Knight, R.T. (1998). Frontal lobe contributions to theory of mind. Journal of Cognitive Neuroscience, 10, 640-656. 15. Theory of mind in old adults: .the performance on happé's stories and faux pas stories. Psychologia.2006; 49(4): 228-237. 16. N Kaland , A M Nielsen, L Smith, E L Mortensen, K Callesen, D Gottlieb .The Strange Stories test--a replication study of children and adolescents with Asperger syndrome .Eur Child Adolesc Psychiatry (2005); 14:73–82 17. Wang, W.-H.; Shih, Y.-H.; Yu, H.-Y.; Yen, D.-J.; Lin, Y.-Y.; Kwan, S.-Y.; Chen, C.; Hua, M.-S. Theory of mind and social functioning in patients with temporal lobe epilepsy. Epilepsia 2015, 56, 1117–1123. 18. Broicher, S.D.; Kuchukhidze, G.; Grunwald, T.; Krämer, G.; Kurthen, M.; Jokeit, H. "Tell me how do I feel"—Emotion recognitionand theory of mind in symptomatic mesial temporal lobe epilepsy. Neuropsychologia 2012, 50, 118–128. 19. G M Tallarita , R Ciuffini , K Turner , B Pucci , A Parente , A R Giovagnoli .Social Cognition in Idiopathic Generalized Epilepsies and Nonlesional Temporal Lobe Epilepsy.Acta Neurologica Scandinavica 2023(2):1-11. 20. Morou, N.; Papaliagkas, V.; Markouli, E.; Karagianni, M.; Nazlidou, E.; Spilioti, M.; Afrantou, T.; Kimiskidis, V.K.; Foroglou, N.;Kosmidis, M. Theory of Mind impairment in focal versus generalized epilepsy. Epilepsy Behav. 2018, 88, 244–250. 21. Realmuto, S.; Zummo, L.; Cerami, C.; Agrò, L.; Dodich, A.; Canessa, N.; Zizzo, A.; Fierro, B.; Daniele, O. Social cognition dysfunctions in patients with epilepsy: Evidence from patients with temporal lobe and idiopathic generalized epilepsies. Epilepsy Behav. 2015, 47, 98–103. 22. Elger, C.E.; Helmstaedter, C.; Kurthen, M. Chronic epilepsy and cognition. Lancet Neurol. 2004, 3, 663–672. 23. Giovagnoli, A.R. Theory of mind across lifespan from ages 16 to 81 years. Epilepsy Behav. 2019, 100, 106349.